(Molecular Pharmacology and Chemical Biology Graduate Program)
Dissertation: Caveolin-1 Mediated p53 Activation in Stress Induced Premature Senescence (SIPS) and Its Antagonistic Pleiotropic Implications in Cancer.
University of Pittsburgh School of Medicine
Dissertation Defense: November 12, 2008 BS
Graduation Date: May 2004
- Assistant Professor tenure-track, Carlow University, Department of Biology, Fall 2011 to Present
- Full-time Instructor, Carlow University, Department of Biology, Fall 2009-Spring 2011
- Temporary Full-time Instructor, Community College of Allegheny County, Department of Biology, Spring 2009
- Adjunct Faculty, Community College of Allegheny County, Summer 2009-Spring 2010
Refereed Journal Articles
1. Bartholomew J, Volonte D, Galbiati F. 2009. Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel MDM2/p53 mediated pathway. Cancer Research. 69(7) 2878-86.
2. Geng X, Bottino R, Balamurugan A, Luppi P, Bartholomew J, Trucco M, Drain P. Imaging insulin biology in live human islets: insulin traffic, secretion, and diabetes through the microscope. Submitted, Traffic, 2009.
3. Bartholomew J, Reichart J, Mundy R, Recktenwald J, Keyser S, Riddle M, Kuruvilla K. 2008. GTP avoidance in Tetrahymena thermophila requires tyrosine kinase activity, intracellular calcium, NOS, and guanylyl cyclase. Purinergic Signaling. 4:171-81
4. Dasari A*, Bartholomew J*, Volonte D, Galbiati F. 2006. Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 MAPK/Sp1-mediated activation of of two GC-rich promoter elements. Cancer Research. 66:10805-14. (* Equal contribution)
5. Hezel M *, Bartholomew J*, Galbiati F. (2005) Caveolin-3: Its importance in muscle function and pathology. Current Genomics 6, 293-314 (*Equal contribution)
6. Lucas J, Riddle M, Bartholomew J, Thomas B, Forni J, Nickerson L, Van Heukelum B, Paulick J, Kuruvilla H. 2003. PACAP-38 signaling in Tetrahymena thermophila involves NO and cGMP. Acta Protozoologica. 43:15-20
7. Rosner B, Bartholomew J, Gaines C, Riddle M, Everett H, Ralapaugh K, Nickerson L, Marshall M, Kuruvilla H. 2003. Pharmacological evidence for a P2Y-like receptor in Tetrahymena thermophila. J. Comp. Physiol. A. 189:781-789.
1. Bartholomew JN, Galbiati F. (2010) Mapping of Oxidative Stress Response Elements of the Caveolin-1 Promoter. Methods in Molecular Biology. 594:409-23
Conferences and Presentations
Peer-Reviewed Conference Presentations
1. Service Learning in Current Topics in Cell Biology Course. National Association of Biology Teachers National Conference. Dallas TX 2012.
Conference Poster Presentations
1. Utilizing Service Learning in an Undergraduate Cell Biology Course to Raise Awareness of Scientific Literacy in the Community. Craven, M, Cushny C, Bartholomew J. NABT National Conference, Dallas TX 2012
1. Caveolin-1 regulates the antagonistic pleiotropic properties of cellular senescence through a novel MDM2/p53 mediated pathway. Bartholomew J, Galbiati F. Biomedical Graduate Student Association Student Symposium and the Department of Pharmacology Annual Retreat. 2008
2. The Caveolin-1 scaffolding domain is sufficient to bind and sequester MDM2 causing cellular senescence. Bartholomew J, Galbiati F. Biomedical Graduate Student Association Student Symposium and Department of Pharmacology Annual Retreat. 2007
3. Oxidative stress induces premature senescence by stimulating caveolin-1 gene transcription through p38 MAPK/Sp1-mediated activation of two GC-rich promoter elements. Bartholomew J, Dasari A, Volonte D, Galbiati F. American Society for Cell Biology Annual Meeting in San Diego, December 2006, and University of Pittsburgh Institute on Aging: Celebrating Research on Aging Building Collaborations for the Future. 2006
4. Stress Induced Premature Senescence Occurs Through Caveolin-1 Mediated Activation of p53. Bartholomew J, Galbiati F. Biomedical Graduate Student Association Student Symposium and Department of Pharmacology Annual Retreat. 2006
5. Stress induced premature senescence occurs through caveolin-1 mediated activation of p53. Bartholomew J, Galbiati F. Biomedical Graduate Student Association Student Symposium 2006.
6. Oxidative stress induces translocation of MDM2 to caveolae in fibroblasts. Bartholomew J, Galbiati F. Biomedical Student Graduate Association Student Symposium 2005.
7. Chemorepellent effect on Tetrahymena thermophila. Bartholomew J. NASA/ Ohio Space Grant Consortium 2003-2004 Scholar/ Fellow Student Journal.
8. Intracellular calcium is required for GTP signaling in Tetrahymena thermophila. Bartholomew J and Kuruvilla H. 43rd American Society for Cell Biology Annual Meeting in San Francisco, December 2003.
9. GTP signals through a tyrosine kinase pathway in Tetrahymena thermophila. Bartholomew J. NASA/ Ohio Space Grant Consortium 2002-2003 Scholar/Fellow Student Journal.
1. Animals and Science, Stefanie L. Graban’s Freshman Biology courses, Western Vance High School, Henderson, NC, March 2013
2. Chemorepellent effect on Tetrahymena thermophila. NASA / Ohio Space Grant Consortium Scholarship Symposium, Ohio Aerospace Institute, April 2004.
3. GTP signals through a tyrosine kinase pathway in Tetrahymena thermophila. Technology Resource Council Annual Meeting, Cedarville University, April 2003.
4. GTP signals through a tyrosine kinase pathway in Tetrahymena thermophila. NASA / Ohio Space Grant Consortium Scholarship Symposium, Ohio Aerospace Institute, April 2003.
Anatomy and Physiology 1 and 2
Experimental Methods in Organismal Biology
Current Topics in Cell Biology (Service Learning)
Experimental Methods in Molecular and Cellular Biology
Community College of Allegheny College
Introduction to Biological Science
Anatomy and Physiology 1 and 2
National Association of Biology Teachers Professional Conference, Dallas TX, November 2012
Carlow University Advising Workshop, Fall 2011
Carlow University Faculty Discussion Group, 2011-2012
Lilly Conferences on College and University Teaching, Washington DC, June 3-5, 2010
Pittsburgh Technology Resource Council Regional STEM Conference, Pittsburgh PA, August 2010
COMMITTEE WORK AND SERVICE
Academic Computing Committee, 2011-present (Chair for 2013)
Middle States Commission on Higher Education Self Study Subcommittee on Institutional Effectiveness, present
Faculty Campaign Committee, 2011-2012
Formative Assessment of Classroom Teaching (FACT) consultant, 2012-present
STEM working group for the Division of Natural Sciences and Mathematics, 2011-present
Faculty Evaluation Manual, 2011-2012
New Student Recruitment Breakfasts, 2009-present
Judge for Pittsburgh Regional Science Fair Whalen Scholarships, 2011-present
Intel International Science and Engineering Fair Grand Award Judge, Pittsburgh, PA, May 2012
National Institute of Health F31 AG032182, Ruth L. Kirschstein National Research Service Awards Pre-Doctoral Grant, Caveolin-1's Role in Stress Induced Premature Senescence, 08/06/2008-08/05/2010, $40,972. Grant Priority Scores of 139 and 117
Department of Pharmacology Fellowship, 2006-2008
NIH Pharmacological Sciences Pre-doctoral Training Grant T32GM008424 2005-2006
Recipient, Ruth L. Kirschstein National Research Service Award for Individual Pre-doctoral Fellows, 2008-2009
Department of Pharmacology Fellowship, 2006-2008
NIH Training Grant, 2005-2006
NASA / Ohio Space Grant Consortium Scholarship, 2002-2004
Senior Science Research Award in Biological Science from Cedarville University, 2004
Graduated from Cedarville University with Honors, 2004
Dean’s list at Cedarville University Department of Science and Mathematics, Fall 2001-Spring 2004
John Franko Scholarship for Science Cedarville University, 2000
Cedarville University’s Faculty and Founder’s Scholarship, 2000
National Association of Biology Teachers, 2010 - present
American Society of Cell Biology, 2006-2007